Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif
The spike protein is the main protein component of the SARS-CoV-2 virion surface. The spike receptor-binding motif mediates recognition of the human angiotensin-converting enzyme 2 (hACE2) receptor, a critical step in infection, and is the preferential target for spike-neutralizing antibodies. Post-translational modifications of the spike...